Monica
💫 Summary
The video discusses the relationship between autophagy, intermittent fasting, and loose skin after weight loss. It explores the scientific research suggesting that fasting and autophagy can help maintain skin elasticity and prevent loose skin. However, it also emphasizes the importance of consulting with a doctor before attempting any fasting or dietary changes.
✨ Highlights📊 Transcript
Autophagy and intermittent fasting can help with loose skin after weight loss by maintaining skin elasticity.
00:00
Loose skin is a common issue after significant weight loss.
Surgery is an option, but some people prefer natural methods.
Fasting and autophagy can help the skin stay elastic.
Loose skin is caused by the loss of skin elasticity during weight loss.
Prolonged fasting can potentially help prevent loose skin by promoting autophagy, a process of cellular recycling.
02:59
Long-term fasting studies have shown that test subjects who lost significant weight did not experience loose skin.
Autophagy, or the recycling of cells, is believed to play a role in preventing loose skin.
Autophagy research has progressed rapidly since the 1960s, with a Nobel Prize being awarded for the study in 2016.
Autophagy may have benefits for neurodegenerative diseases, psychiatric diseases, and autoimmune diseases, and may also increase energy levels.
05:58
Autophagy may help clean cells and slow down diseases like Parkinson's and Alzheimer's.
Caloric restriction and low carb/ketogenic diets may induce autophagy.
Autophagy and fasting have been shown to increase energy levels.
There may be potential benefits of autophagy and fasting for the immune system and autoimmune diseases.
It is difficult to track when autophagy actually happens in the body, especially in humans.
Autophagy plays a crucial role in maintaining skin integrity and preventing the buildup of waste products in aging fibroblasts.
08:58
Autophagy helps clean up debris and waste products in fibroblasts.
Aging fibroblasts have more waste products and are less efficient at recycling them compared to younger fibroblasts.
The inability of fibroblasts to keep up with and eliminate waste products may lead to skin aging and the development of wrinkles and loose skin.
Fasting and caloric restriction can increase autophagy, which may help with loose skin, but the optimal parameters for humans are not yet known.
11:56
Fasting and caloric restriction are potent non-genetic autophagy stimulators.
Autophagy in mice begins after about 24 hours of fasting, but the time limit for humans is unknown.
Dr. Jason Fung suggests that autophagy sets in at around the 24-hour point, with maximum benefits at 32-36 hours.
Doing a 24-hour fast may be more attainable and still provide significant benefits compared to longer fasts.
00:00hey this is Dr John with the health EMD
00:03and today we're going to do is talk
00:05about autophagy and loose skin or how
00:08intermittent fasting can increase
00:10autophagy and help with that loose skin
00:11and this really goes out to those folks
00:13that have done the hard work they've
00:15finally lost those extra pounds they may
00:17have had a pretty significant amount of
00:19weight loss and now they're left with a
00:21lot of this loose hanging skin maybe
00:22like underneath their arms
00:25um around their stomach that just
00:26doesn't seem to go away and I see
00:27patients in the clinic with this and
00:29it's one of these things can be really
00:30distressing after you've gone through
00:32the hard work as far as losing that
00:34weight
00:36and you really can develop almost
00:38anywhere too you can develop around them
00:40now they run abdomen you may see it
00:42around the thighs buttocks and other
00:44areas too and it's really the stubborn
00:46loose skin that people are really
00:48frustrated with and can really affect
00:50self-esteem
00:51um one of the most common ways that
00:53people handle this is to go off to the
00:55plastic surgeon and they have surgery
00:57for this and while that's definitely an
00:59option for some folks or maybe other
01:00folks are looking for a different way or
01:02more natural way other than surgery to
01:05take care of that loose skin
01:08so what I want to do today is just talk
01:10about some of the scientific research
01:12out there that talks about autophagy or
01:14fasting for helping with with the loose
01:16skin after weight loss or during weight
01:18loss and how do you actually prevent
01:19that loose skin from developing
01:21and one of the things that I want to
01:23talk about is how fasting and autophagy
01:25can actually help that skin stay elastic
01:27because that's why what the issue is
01:28that skin loses its elasticity during
01:31the weight loss and that's why I'll kind
01:33of hang down you'll see it kind of you
01:35know hang down like what uh women will
01:37call like those bat wings that they get
01:39um after or what we'll see around the
01:42abdomen as well too so
01:45just a quick review uh or a quick thing
01:48to point out it just you know I think
01:50people have a Mis misconception about
01:53how this all works how fast and
01:55autophagy can actually work
01:57it doesn't literally eat up the loose
02:00skin it actually helps your body become
02:02help that skin become more elastic so
02:05let's just kind of Jump On In and kind
02:07of talk about a you know a little bit of
02:10a definition what is autophagy okay and
02:12autophagy's actually a Greek word
02:14so the first part is auto self and fagi
02:19which is for eating so essentially
02:20self-eating is what autophagy means and
02:23so it's really where
02:25for lack of a better term the body
02:27really starts to eat eat itself or reuse
02:30parts of itself so what's really
02:32happening it's more of a recycling
02:34process that's happening and it's pretty
02:36interesting because this research is is
02:38relatively new
02:40um
02:41in medicine so probably since just the
02:431960s
02:45and so how do we induce autophagy really
02:48it's by the absence of external food so
02:50in other words by fasting for several
02:52hours and there's antidotal studies that
02:54go back even to like the 1920s and 1930s
02:56where they used to do these locked Ward
02:59fasting studies which you know we can't
03:02do nowadays just because ethical uh
03:05standards and they would have
03:08their research subjects lose 100 pounds
03:10120 pounds and come out of there with no
03:12loose skin so really interesting that if
03:14you do these long prolonged fastings
03:17we're talking you know three months six
03:19months and in one case even upwards of a
03:21year
03:23um and the test subjects didn't have any
03:25of the loose skin afterwards so the
03:27thought being that this autophagy or
03:28this recycling of the of the cells can
03:31help as far as that loose skin
03:35so the other thing obviously is make
03:38sure that before you start this you
03:40check with your doctor okay and that's
03:43pretty much going to be you know sort of
03:46anything else that you're going to hear
03:47on from me is you know I'm not your
03:49doctor this is general information on
03:52not specific medical advice so
03:54you know learn a little bit but then
03:56also talk to your doctor about it see if
03:58this is right for you with your specific
04:01medical issues
04:02um and so that kind of goes without
04:04saying but let's talk a little bit about
04:06what the research is out there at least
04:08on autophagy and fasting and weight loss
04:11and on loose skin
04:13so again I said before you know these
04:15studies on autophagy really start back
04:16from the 1960s with some of the Belgian
04:19um scientists and actually was a uh
04:23that's where the term atava Julie came
04:25from and it's really progressed pretty
04:26rapidly where
04:28you know in 2016 uh Japanese biologist
04:31uh the scenario
04:34um osumi won the actual Nobel Prize in
04:36physiology for his work in in autophagy
04:39and while his research really looked at
04:41yeast cells and how they promoted
04:43autophagy he was also able to show how
04:46that could apply to human human cells as
04:48well too so that's a pretty rapid
04:50advancement in this field over what 50
04:53years
04:55um or less than 50 years
04:57so where the Nobel Prize has been
05:00awarded for this for This research um
05:04another way to think about autophagy is
05:06also more like a housekeeping or
05:08cellular housekeeping kind of cleaning
05:10up or maybe even like a quality control
05:12autophagy is really designed to
05:16gradually reduce damage that happens in
05:19the cells because as we age and as those
05:21cells age there is debris and there's
05:22damage that happens that needs to get
05:24cleaned up and the more damage it
05:26doesn't get cleaned up it's just like if
05:28you don't clean up your house you get
05:29more and more
05:30um stuff and trash that builds up and
05:33builds up and all of a sudden soon
05:34you're a hoarder that you know you just
05:36can't function you can't walk around the
05:37house while your cells are the same way
05:39and they become less efficient they
05:42can't process and do the job they're
05:44supposed to do
05:45um but it's really interesting some of
05:48the research that's coming out on this
05:49on autophagy now so now we're looking
05:51even at some of these neurodegenerative
05:53diseases so if we're talking about
05:54Alzheimer's or maybe Parkinson's disease
05:56that there's some research that suggests
05:58that maybe autophagy can actually slow
06:00down those diseases and maybe that's one
06:02of the focuses that we need to to look
06:05at with Parkinson's or Alzheimer's is
06:07how do we induce
06:09um
06:09a greater amount of autophagy to have
06:11the cells really clean themselves up
06:15and that's one of the reasons why there
06:17may be a benefit to caloric restriction
06:19in Alzheimer's patients and Parkinson's
06:22patients as well too is because of this
06:23induction of autophagy uh really
06:25interesting stuff and that's also I
06:27think we're low carb or ketogenic diets
06:29have a role to play as well too
06:31now there's also some studies out there
06:34that look at autophagy and fasting with
06:35depression schizophrenia so all across
06:38the board as far as neurodegenerative
06:39diseases and some of these psychiatric
06:41diseases
06:42now autophagy and fasting has also been
06:45shown to help with increased energy so
06:46if you've talked to folks or if you've
06:48done a extended fast yourself that's one
06:51of the things that typically people will
06:52talk about is once they get to about 24
06:54hours
06:55it was kind of this break point where
06:57they're almost like euphoric and they
06:58just have this
07:00added energy like it's literally like
07:02having three or four cups of coffee but
07:04obviously without the caffeine and it's
07:07interesting how you know is that due to
07:10Ketone levels is it due to autophagy
07:11what is it um you know research is is
07:14really ongoing but there's also probably
07:16some benefit to the immune system so
07:17folks with autoimmune diseases
07:20um you know are holding out hope that
07:22some of the future research on autophagy
07:24and fasting will will show that maybe
07:26that's a treatment or potential future
07:28treatment for these autoimmune diseases
07:30too
07:32so the one thing that we don't know is
07:34how does how often or what when does
07:37autophagy actually happen in the body
07:38and it's really tough to track in humans
07:41there's research looking at mice and and
07:44other animal studies but it's hard to
07:46kind of apply that to humans so but
07:48there are a couple studies out there
07:49that I found that talk about autophagy
07:52and loose skin so there was a 19 or
07:54excuse me a 2014 study that was done in
07:58Japan that looked at aging fibroblaster
08:00and these are cells that are responsible
08:03for connective tissue in the body and
08:05these connective these fibroblasts
08:07produce collagen which actually gives
08:08skin its elasticity or kind of that
08:11allows the skin to kind of have that
08:13snap back into place so aging
08:15fibroblasts can't make that collagen as
08:17well the skin suffers from a lack of of
08:19that elasticity and that's where you
08:22start getting that hanging skin or that
08:23loose skin so
08:25what they showed in these aging
08:27fibroblasts is that over time that the
08:29these aging fiberglass fiber blast it's
08:32actually got clogged up so kind of waste
08:35products and broken parts and
08:37um really impacted the fibroblasts
08:39ability to function as far as producing
08:41collagen so one of the conclusions from
08:44this Japanese study was that the
08:45Slowdown of autophagy as we age leads to
08:48that deterioration of the dermal
08:50integrity and skin fragility that we see
08:53as we age so is that something where we
08:56need to look at as far as how to keep
08:58inducing a certain level of autophagy as
09:00we age to keep that skin keep those
09:02fiberglass functioning to help out with
09:04the Skin Integrity so there was also
09:06another study done in 2018 this one was
09:09actually out of Korea that looked at and
09:12this Korean study look at it also looked
09:14at autophagy and loose skin as well too
09:16so these scientists in Korea looked at
09:18dermal fibroblasts using a
09:21transmission electron microscope which
09:23is one of these really powerful
09:24microscopes where you can pretty much
09:25blow things up or magnify things up to
09:28about two million times so really look
09:29at the cellular level
09:31so they were actually able to look at
09:33these fibroblasts
09:35under autophagy or under um laboratory
09:38conditions and especially these aging
09:41fibroblasts founded these aging
09:44fibroblasts had more debris had more
09:46waste products produced because they
09:48didn't have the autophagisms to clean
09:52things up so it's almost like you know
09:54if you you know keep putting out your
09:56recycling
09:58um
09:59uh uh container on Wednesdays whenever
10:01it's it's garbage day but there's not
10:03enough recycling trucks to go around and
10:06your recycling is just going to sit
10:07there and build up and build up until
10:09the recycling truck can get there so
10:11again it's kind of that buildup of waste
10:13products and not having enough of these
10:16specialized cells to break them down and
10:18really recycle all the products so
10:20there's a big difference that the Korean
10:22researchers found between the older
10:24fiber glass and the younger fiberglass
10:26as far as how quickly they're able to
10:28recycle
10:29um that cell cellular debris
10:33and it's this inability of the
10:35fibroblast to kind of keep up with and
10:36get rid of that extra weight waste
10:38product that probably results in the
10:40skin aging that leads to the wrinkles it
10:42leads to loose skin everything else that
10:44we kind of associate with aging so just
10:47to kind of you know summarize it these
10:50two studies really looked at a couple
10:51things one we know that fibroblasts make
10:54collagen and collagen prevents loose
10:57sagging skin we also looked at these
11:00studies and it looks like that autophagy
11:02helps these cells especially
11:04specifically these fibroblast cells keep
11:06themselves clean and healthy and that
11:08aging fiberglass suffer from increased
11:11waste production and less autophagy so
11:13when this happens the fibroblasts these
11:15older fibroblasts can't produce a
11:17collagen we need to keep the skin
11:18elastic and then it's that lack of
11:21collagen and turn it leads to the aging
11:23and sagging skin so thought is by
11:25increasing autophagy that we can clean
11:28up these fiberglass and make them
11:29produce collagen again and it kind of
11:31makes sense if you think about it and
11:32these studies then developed um you know
11:35you know their hypothesis that that's
11:37really the link is that autophagy can
11:39help with the loose skin great
11:41so how do we induce autophagy in our own
11:44body is there a pill you can take is
11:46there a magic wand you can wave well
11:48it's it's actually a little bit simpler
11:50than that so
11:53and really what we're talking about or
11:54what the next I think the next research
11:56is looking at is you know
11:59does increase autophagy then get rid of
12:02the the loose skin and it's interesting
12:04because there are literature reviews out
12:05there there's one that's published in
12:072018 that looked at this and found that
12:09fasting caloric restriction to be one of
12:11the most uh potent non-genetic autophagy
12:15stimulators and that was also really no
12:18side effects with it so something to
12:20think about as far as you know future
12:22research
12:23for autophagy in this loose skin
12:28so how do we induce autophagy so if we
12:31look at the studies in mice decreasing
12:33calories by about 40 percent from normal
12:35induces autophagy so caloric
12:39restrictions one way to do it fasting is
12:41also another way to do it as well too
12:45but we don't really have the the right
12:47parameters yet for humans so we know
12:49that in mice autophagy begins in about
12:5124 hours of fasting but we don't know
12:54what that times uh limit is for humans
12:57yet but some experts will say about 16
12:59hours uh I think more of them will say
13:02around 24 hours similar to the uh to the
13:04mice but we don't know if you need to go
13:07longer for that as well too or how often
13:10you need to do the fasting to induce
13:13autophagy if you followed Dr Jason Fung
13:16who's a Canadian nephrologist and really
13:18one of the the docs who's really kind of
13:20jumped into intermittent fasting with
13:22both feet um
13:24you're right at the beginning and
13:25someone who's I've looked at a lot of
13:27his stuff and really respect you know he
13:30believes that autophagy sets in at about
13:31the 24-hour point and that really
13:34probably a max out or you get the
13:35maximum benefits around you know 32 36
13:38hours so you don't need to do these two
13:40three four day fast necessary to to get
13:43the the big benefits from autophagy and
13:47probably something that's probably more
13:48attainable for most folks is doing that
13:5024-hour fast rather than trying to go
13:52two three four five day fast and I think
13:55you know I think there's some issues if
13:57you really try to fast for that length
13:58of time and how often you're trying to
14:01do it so I definitely you know don't
14:04take this as a recommendation be doing
14:06you know multiple day fast frequently to
14:08do autophagy
14:10um
14:11and the interesting thing is when you do
14:13these fast the body actually has to turn
14:15in on itself and look okay what can we
14:17recycle and it starts looking at you
14:20know all these other cells that have the
14:22all this waste and debris built up in
14:24them and that's where the autophagy
14:25probably kicks in so it's interesting to
14:28kind of see that that may be the the
14:30kind of sweet spot that we need to look
14:31at so
14:33fasting definitely leads autophagy which
14:35then again we think or potentially can
14:37lead to that tighter healthier skin as
14:39those fiberglass fibroblast a little
14:42tongue twister as those fibroblasts
14:44start to produce more collagen Okay so
14:49again how long do you shoot you fast for
14:51one number one talk with your doctor
14:54okay but in general probably somewhere
14:57between 24 to 36 hours
15:00that is probably again about The Sweet
15:02Spot
15:04with that but you need to also be
15:06careful of some other things because
15:08there's some downsides with too much
15:09fasting and especially if you have a
15:11history of Eating Disorders whether it's
15:12anorexia or bulimia then really
15:17you know you need to really talk to your
15:20talk to your medical team about whether
15:22or not fasting is right for you
15:25um the last thing we want to have happen
15:27is for you to tip back into into
15:29anorexia so you really have to tread
15:31cautiously if you have a history of
15:32eating disorders and using intimate
15:35fasting but there are other ways to
15:38promote autophagy which is good news so
15:42fasting is only going to be one of the
15:44ways to do that
15:46another way to do that is also exercise
15:48and a couple different types of exercise
15:51I think you've heard me talk about it
15:52quite a bit on this channel uh not a
15:55huge cardio fan but endurance exercise
15:57can definitely induce some autophagy
15:59resistance exercise so weightless
16:01lifting and again if you follow me for
16:03any bit of time I'm a bigger fan of
16:05lifting weights and resistant exercise I
16:08am of cardio doesn't mean you can't do
16:10cardio I just think that your primary
16:12focus needs to be on lifting things and
16:15getting stronger and building up that
16:16lean muscle mass
16:18but that's one of the things we're going
16:20to look at because as you start uh you
16:23know doing that resistance exercise
16:24there's a breakdown of muscle protein
16:26there's kind of a cleanup system that
16:28has to happen and then their thoughts or
16:31some research are suggesting that if you
16:32combine that resistance exercise with
16:35intermittent fasting that you can
16:37actually really promote more autophagy
16:40throughout the body which can be again
16:42hopefully a healthy
16:45thing especially if you're trying to get
16:47rid of that loose skin so
16:50so diet exercise are probably the two
16:53key things for inducing autophagy which
16:55again will clean up those fibroblasts
16:57and then help with that loose skin this
17:00doesn't work for everybody so it's not a
17:02Panacea it's not going to you know melt
17:04off the the skin if especially if you've
17:06lost you know 100 150 pounds but it may
17:08help okay so again talk to your doctor
17:10about this uh before you start any type
17:13of fasting program even if it's
17:14intermittent fasting okay make sure
17:16they're on board especially if you're
17:18going through weight loss and you're on
17:20medications your medication doses may
17:23change as you're losing the weight loss
17:25so your doctor really needs to be on
17:26board and really kind of monitoring you
17:28know how quickly or when they need to
17:30adjust those medicines
17:31um
17:32and you but hopefully this has been
17:33helpful so if you have questions uh type
17:36them down the comment box read through
17:38the article it'll have links to the
17:39research as well too that kind of talks
17:42about what I've talked about in this
17:44video again I'm Dr John Martinez from
17:46the health EMD
17:47to be here and two other requests please
17:50hit the like button and subscribe so you
17:52know when we have other videos coming
17:54out thanks again and stay healthy
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FAQs about This YouTube Video

1. How does intermittent fasting relate to loose skin after weight loss?

Intermittent fasting has been shown to promote autophagy, a process that helps maintain skin elasticity and prevent loose skin after weight loss. It stimulates the body's natural healing process, reducing the risk of loose skin.

2. What is the relationship between autophagy and loose skin?

Autophagy plays a crucial role in maintaining skin elasticity by removing damaged cells and promoting the regeneration of healthy skin cells. This process is beneficial in minimizing the risk of loose skin after weight loss.

3. Can fasting help prevent loose skin after weight loss?

Research suggests that fasting can activate autophagy, which in turn supports skin health and elasticity. By promoting the body's natural repair mechanisms, fasting may help prevent loose skin following weight loss.

4. What precautions should be taken before attempting fasting for skin health?

It is essential to consult a healthcare professional before making any changes to your diet or fasting routine, particularly if you have underlying health conditions. This ensures that fasting is safe and suitable for your individual health needs.

5. How can autophagy contribute to maintaining skin elasticity?

Autophagy removes damaged cells, protein aggregates, and toxins from the skin, promoting the regeneration of healthy skin cells. This process helps maintain skin elasticity and reduces the likelihood of loose skin after weight loss.

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